TY -JOUR
AU -Yu-Wei Lee
AU -Jia-Jun Liao
AU -Yu-Ting Kuo
AU -Yu-Ting Huang
AU -Yu-Chi Chen and Hsinyu Lee
TI -The Expression Profiles of Lysophospholipid Receptors (LPLRs) in Different Endothelial Cells
PY -2006
DA -0000-00-00
JO -Taiwania
VL -51
IS -1
SP -11
EP -24
UR -https://taiwania.ntu.edu.tw/abstract/475
AB -Sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are two bioactive lysophospholipids (LPLs), stored primarily in platelets and released during platelet activation. Both LPLs are capable of regulating endothelial cell functions. The physiological functions of S1P and LPA are mediated by interacting with eight different G-protein coupled receptors: S1P1 through 5 and LPA1 through 3, which activate three different heterotrimeric GTP proteins－including Gi、Gq and G(12/13). The expression of LPL receptors in endothelial cells would affect the responses of S1P and LPA to these cells. There is no previous report discussing the expression profiles of LPL receptors in different endothelial cells from various species. In this study, we aim to investigate the expression profiles of S1P and LPA receptors in different endothelial cells isolated from human, rat, mouse and bovine origin. We used RT-PCR to determine LPLs receptors expression profiles in different endothelial cells. Our results indicated that endothelial cells from various species express different LPL receptors. Endothelial cells isolated from the same source of different species also had different LPLs receptors expression profiles. Therefore, different endothelial cells should respond to LPLs in different manners.
DO -10.6165/tai.2006.51(1).11