TY -JOUR
AU -Chung-Lun Lu and Shiu-Nan Chen
TI -Magnesium Enhanced Fibrinolytic Activity of Protease from Schizophyllum commune
PY -2010
DA -2010-06-15
JO -Taiwania
VL -55
IS -2
SP -117
EP -122
UR -https://taiwania.ntu.edu.tw/abstract/1126
AB -Prevention and therapy of thrombotic diseases have attracted much attention in developed countries during recent years. Investigators have been looking for cheaper and safer thrombolytic agents for therapy of thrombotic diseases. Recently, we have discovered a fibrinolytic protease from Schizophyllum commune. In this study, the protease was proven to degrade blood clot effectively. Seven divalent metal ions were used to test the selectiveness on enhancing protease activity. The treated rat blood was traced by thromboelastography to assess the viscoelastic properties of whole blood. As the result, fibrinolytic activity of the protease was enhanced remarkably by Mg2+ in reducing the strength of blood clot and showed the innovative anti-thrombotic effects. This is the first study of anti-thrombotic effects from fungal-derived fibrinolytic protease using thromboelastography and delineates the efficacy of magnesium supplementation in enhancement of thrombolytic activity from S. commune fibrinolytic protease.
DO -10.6165/tai.2010.55(2).117